Technical Abstract: Web blight, caused by Thanatephorus cucumeris (Frank) Donk (anamorph: Rhizoctonia solani Kühn), is a serious disease in the humid tropics that reduces both yield and seed quality. Common bacterial blight (CBB), caused by Xanthomonas axonopodis pv. phaseoli (Smith) Vauterin et al., and Bean common mosaic virus (BCMV) pose a threat to common bean (Phaseolus vulgaris L.) production throughout the world. The development and release of dry bean cultivars with enhanced levels of resistance to these and other diseases is an important goal of the University of Puerto Rico breeding program. PR0401-259, (Reg. No. GP-____, PI _______), and PR0650-31, (Reg. No. GP-____, PI _______) are multiple disease resistant bean germplasm lines adapted to the humid tropics that were developed and released cooperatively in 2010 by the University of Puerto Rico Agricultural Experiment Station, the United States Department of Agriculture-Agricultural Research Service and the Escuela Agrícola Panamericana in Honduras. PR0401-259 is a pink bean line and PR0650-31 is a black bean line that possess the resistant allele at the I locus conferring resistance to bean common mosaic virus. Both lines have high levels of resistance to common bacterial blight and moderate levels of resistance to web blight. PR0401-259 also has the bgm gene for resistance to Bean golden yellow mosaic virus. In field trials conducted in Puerto Rico, PR0401-259 and PR0650-31 did not show symptoms to endemic races of rust caused by Uromyces appendiculatus (Pers.) Unger. In field trials conducted in Puerto Rico from 2006 to 2010, PR0401-259 and PR0650-31 produced mean seed yields of 1,788 and 1,926 kg ha-1, respectively, whereas the check variety ‘Talamanca’ had a mean seed yield of 1,593 kg ha-1. PR0401-259 and PR0650-31 should serve as useful sources of resistance for bean breeding programs in the humid tropics or temperate locations where web blight, CBB, and BCMV are important diseases.