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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #266941
Title: Brief report: molecular characterization of a novel reassorted pandemic H1N1 2009 in Thai pigs

Author
item Kitikoon, Pravina
item SRETA, DONRUETHA - Chulalongkorn University
item NUNTAWAN NA AYUDHYA, SUPARLARK - Chulalongkorn University
item WONGPHATCHARACHAI, MANOOSAK - Chulalongkorn University
item LAPKUNTOD, JIRADEJ - Chulalongkorn University
item PRAKAIRUNGNAMTHIP, DUANGDUEAN - Chulalongkorn University
item BUNPAPONG, NAPAWAN - Chulalongkorn University
item SURADHAT, SANIPA - Chulalongkorn University
item THANAWONGNUWECH, ROONGROJE - Chulalongkorn University
item AMONSIN, ALONGKORN - Chulalongkorn University

Submitted to: Virus Genes
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/7/2011
Publication Date: 8/1/2011
Citation: Kitikoon, P., Sreta, D., Nuntawan Na Ayudhya, S., Wongphatcharachai, M., Lapkuntod, J., Prakairungnamthip, D., Bunpapong, N., Suradhat, S., Thanawongnuwech, R., Amonsin, A. 2011. Brief report: molecular characterization of a novel reassorted pandemic H1N1 2009 in Thai pigs. Virus Genes. 43(1):1-5.

Interpretive Summary: Swine infleuzna virus (SIV) is the causative agent of respiratory disease in pigs. The genome of the SIV consists of eight segments. Characterizing each gene segment can provide valuble information such as the evolution of the studied virus. This study describes the emergence of a newly reassorted H1N1 SIV (rH1N1) in the Thai swine population. The rH1N1 was detected from pigs during a respiratory disease outbreak. The rH1N1 was a reassortant between the pandemic H1N1 2009 (pH1N1) virus and Thai H1N1 SIV that had been endemically circulating in Thai pigs for over a decade. Interestingly, the emergence of rH1N1 was detected after a short period of the pH1N1 introduction into the Thai pig population. The finding confirms that pigs are capable of generating new reassorted SIVs and highlights to importance of continuing SIV surveillance and genetic characterization. Data reported here will benefit swine practioners, swine producers and veterinarians who seek to prevent and control SIV in pig farms.

Technical Abstract: For the past 10 years, endemic swine influenza H1 viruses in Thailand have been characterized as reassortants of swine virus genes from swine influenza viruses (SIV) in US and European pigs. Here the authors report the emergence of a novel reassorted H1N1 (rH1N1) virus consisted of human, avian, and swine virus genes from the pandemic H1N1 2009 (pH1N1) virus with a neuraminidase (NA) gene from a Thai swine H1N1 (ThH1N1) isolate. The rH1N1 virus was detected in nursery pigs during a respiratory disease outbreak in central Thailand in early 2010. The rH1N1 virus was repeatedly isolated from infected pigs, suggesting that it can transmit efficiently among the pig population. The appearance of rH1N1 virus in the field occurred within months of the introduction of pH1N1 virus into the Thai swine population in late 2009. The finding highlights the role of pig in generating newly reassorted influenza A viruses and also the significance of continuing disease surveillance and genetic characterization of SIV in pigs.