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Title: Detection of lymphoid leukosis tumors in white leghorn chickens of line ALV6 that is resistant to subgroups A and E avian leukosis virus and maintained under specific pathogen-free conditions

Author
item Fadly, Aly
item Mays, Jody
item Dunn, John
item Kulkarni, Gururaj - Raj

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 5/2/2011
Publication Date: 7/16/2011
Citation: Fadly, A.M., Mays, J.K., Dunn, J.R., Kulkarni, G. 2011. Detection of lymphoid leukosis tumors in white leghorn chickens of line ALV6 that is resistant to subgroups A and E avian leukosis virus and maintained under specific pathogen-free conditions [CD-ROM]. American Veterinary Medical Association (AVMA) Convention, July 16-19, 2011, St. Louis, Missouri. Paper No. 11129.

Interpretive Summary:

Technical Abstract: Chickens from Avian Disease and Oncology Laboratory (ADOL) line alv6 that is known to be resistant to infection with subgroups A and E avian leukosis virus (ALV) were vaccinated at hatch with a Marek’s disease (MD) vaccine containing serotypes 1, 2 and 3 MD viruses, and were maintained under specific-pathogen free (SPF) conditions from the day of hatch until 56 weeks of age. Lymphoid leukosis tumors were detected in several chickens that died after 20 weeks of age. Chickens tested negative for all subgroups of exogenous ALV and for antibodies against ALV of subgroup of A, B and J. Also, tumor tissues tested negative by PCR for the presence of infectious ALV of subgroups A, E, and J. Results suggest the development of spontaneous LL in SPF white leghorn chickens that are resistant to subgroup A and E ALV. The role of using MD vaccines containing all serotypes of MD virus in the development of these tumors will be discussed.