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United States Department of Agriculture

Agricultural Research Service

Research Project: MOLECULAR, CELLULAR, AND REGULATORY ASPECTS OF NUTRITIONAL METABOLISM DURING CHILDHOOD DEVELOPMENT Title: Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis

Authors
item Erez, A -
item Chen, Y -
item Shchelochkov, O -
item Nagamani, S -
item Mian, A -
item Bertin, T -
item Jiang, M -
item Black, J -
item Garg, H -
item Zeng, H -
item Summar, M -
item O'Brien, W -
item Mitch, W -
item Aschner, J -
item Marini, J -
item Bryan, N -
item Lee, B -

Submitted to: Molecular Genetics and Metabolism
Publication Type: Abstract Only
Publication Acceptance Date: March 1, 2009
Publication Date: November 3, 2009
Citation: Erez, A., Chen, Y., Shchelochkov, O.A., Nagamani, S.S., Mian, A., Bertin, T.K., Jiang, M., Black, J.0., Garg, H., Zeng, H., Summar, M., O'Brien, W.E., Mitch, W.E., Aschner, J.L., Marini, J.C., Bryan, N.S., Lee, B. 2009. Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis [abstract]. Molecular Genetics and Metabolism. 98:142.

Technical Abstract: The regulation of nitric oxide synthesis is a complex mechanism, depending on the availability of substrates and the activity of the enzymes involved. Here we describe in a mouse model the channeling of urea cycle intermediates for the recycling of citrulline and the transport of extracellular arginine to sustain an arginine intracellular pool utilized for nitric oxide synthesis.

Last Modified: 12/18/2014
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