ARS | Publication request: PICOT, a novel monothiol glutaredoxin, plays a role in postembryonic growth and cardiac function in mice under nutritional perturbation

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: February 22, 2009
Publication Date: April 22, 2009
Citation: Cheng, N. PICOT, a novel monothiol glutaredoxin, plays a role in postembryonic growth and cardiac function in mice under nutritional perturbation [abstract]. Journal of Federation of American Societies for Experimental Biology. 23:617.8.

Technical Abstract: Using a transgenic mouse model, the CNRC scientist has shown that a novel redox-sensitive protein, PICOT (also termed Glutaredoxin), is an important mediator in cellular redox homeostasis that regulates cell proliferation and oxidative stress signaling. Furthermore, this study for the first time demonstrates that PICOT plays a critical role in post-embryonic growth and cardiac function under nutritional perturbation.