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Title: Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal

Author
item GAZZANEO, MARIA - Children'S Nutrition Research Center (CNRC)
item SURYAWAN, AGUS - Children'S Nutrition Research Center (CNRC)
item ORELLANA, RENAN - Children'S Nutrition Research Center (CNRC)
item MURGAS-TORRAZZA, ROBERTO - Children'S Nutrition Research Center (CNRC)
item NGUYEN, HANH - Children'S Nutrition Research Center (CNRC)
item WILSON, FIONA - Children'S Nutrition Research Center (CNRC)
item FIOROTTO, MARTA - Children'S Nutrition Research Center (CNRC)
item DAVIS, TERESA - Children'S Nutrition Research Center (CNRC)

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 2/24/2010
Publication Date: 4/24/2010
Citation: Gazzaneo, M.C., Suryawan, A., Orellana, R.A., Murgas-Torrazza, R., Nguyen, H.V., Wilson, F.A., Fiorotto, M.L., Davis, T. 2010. Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal [abstract]. Federation of American Societies for Experimental Biology Conference, Session: Energy and macronutrient metabolism II, April 24-28, 2010, Anaheim, California. 24: 220.5.

Interpretive Summary:

Technical Abstract: Newborns experience a high rate of growth that is driven by elevated rates of skeletal muscle protein synthesis. Nutritional consumption stimulates this protein synthesis, however the time it takes for changes to occur in different tissues has not been determined. The aim of this study was to evaluate the time course of the changes in protein synthesis rates and translation initiation factor activation in skeletal muscle and visceral tissues after a meal. Our results suggest that feeding stimulates mTOR signaling in skeletal muscle and visceral tissues yet, mTOR activation alone was not sufficient to stimulate protein synthesis in all tissues. These findings are important for researchers interested in muscle development in newborns.