Technical Abstract: Medusahead (Taeniatherum caput-medusae (L.) Nevski) is an exotic annual grass invading rangelands in the western United States. Medusahead is a serious management concern because its decreases biodiversity, reduces livestock forage production, and degrades ecological function of rangelands. Despite the obvious importance of ranchers as partners in preventing and managing medusahead infestations, little is known about their perspectives, opinions, and behaviors concerning medusahead management. We present the results of a survey of 600 ranchers operating on sagebrush steppe rangeland in a three-county area encompassing over 7.2 million hectares in southeast Oregon. The primary objective of this research was to determine whether the presence of medusahead on a ranch influenced its operator’s perceptions, opinions, and behaviors concerning medusahead control and prevention. Ranchers operating on medusahead-infested rangeland were more likely to indicate increased awareness and concern about medusahead and the potential for its continued expansion (P < 0.05). Ranchers operating on rangeland invaded by medusahead were more likely to indicate using measures to prevent the spread of medusahead and other invasive plants on rangeland, interest in educational opportunities concerning invasive annual grass management, and plans for controlling invasive annual grasses in the future (P < 0.05). This study revealed an alarming trend in which knowledge and awareness of invasive plants are often lacking until individuals directly experience the negative consequences of invasion. Information campaigns would raise knowledge awareness of invasive plants and their impacts. Survey results suggest information campaigns aimed at bolstering awareness of invasive species among ranchers must carefully consider appropriate delivery methods. Web- or computer-based invasive plant information and tools were largely unpopular among ranchers, whereas traditional forms of information delivered in brochures/pamphlets or via face-to-face interaction were preferred (P < 0.05).