Page Banner

United States Department of Agriculture

Agricultural Research Service

Research Project: DIET, INFLAMMATION AND PREVENTION OF CHRONIC DISEASE

Location: Immunity and Disease Prevention Research Unit

Title: Toll-like receptors in the pathogenesis of inflammatory diseases

Authors
item Lee, Jun -
item Hwang, Daniel
item Lee, Joo -

Submitted to: Trade Journal Publication
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: March 3, 2009
Publication Date: May 1, 2009
Repository URL: http://www.informaworld.com/smpp/content~db=all~content=a772828562
Citation: Lee, J.K., Hwang, D.H., Lee, J.Y. 2009. Toll-like receptors in the pathogenesis of inflammatory diseases. Journal of Organ Dysfuntion. 5:2,119-128, 2009.

Interpretive Summary: Toll-like receptors (TLRs) are newly established immune receptors which are critical for host defense through the activation of both innate and adaptive immunity. TLRs can recognize molecules with both microbial and non-microbial origins. Emerging evidence now suggests that TLRs are implicated in the pathogenesis of many chronic diseases, including sepsis, atherosclerosis, ischemia/reperfusion-mediated organ dysfunction, rheumatoid arthritis, diabetes, and cancer. Therefore, an understanding of the role of TLRs in inducing chronic inflammation will provide new insights to help design an effective intervention strategy for inflammatory diseases.

Technical Abstract: Toll-like receptors (TLRs) are newly established immune receptors which are critical for host defense through the activation of both innate and adaptive immunity. TLRs can recognize molecules with both microbial and non-microbial origins. Emerging evidence now suggests that TLRs are implicated in the pathogenesis of many chronic diseases, including sepsis, atherosclerosis, ischemia/reperfusion-mediated organ dysfunction, rheumatoid arthritis, diabetes, and cancer. Therefore, an understanding of the role of TLRs in inducing chronic inflammation will provide new insights to help design an effective intervention strategy for inflammatory diseases.

Last Modified: 4/20/2014