Technical Abstract: Coffee Senna, [Senna occidentalis(L.)] and its wild allied species are underutilized legumes. The USDA, ARS, PGRCU curates 47 accessions of 18 Senna species. Coffee senna and its wild allied species were transplanted from about 30-day-old seedlings to the field at Griffin, GA around 01 June 1996, 2002, and 2004-2007. At 50% maturity, 14 accessions of coffee senna and 8 accessions from its wild relatives were characterized for morphological traits, seed reproduction, and evaluated for regeneration ability. High quality plants regenerated from all accessions produced 1,018 to more than 21,000 total seeds per accession. Coffee senna and several of its wild allies can be successfully grown and regenerated in Griffin, GA. Coefficients of variation and principal component analysis revealed considerable variability among coffee senna accessions for morphological and reproductive traits. Senna species have potential to produce pharmaceutical products and can be grown as ornamental flowering and medicinal plants as well. The flavonoids quercetin and kaempferol found in Senna species have been clinically shown to have an anti-pacreatic cancer property.