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Title: Major histocompatibility complex and host background genes in chickens influence resistance to high pathogenicity avian influenza virus

Author
item Hunt, Henry
item Swayne, David

Submitted to: International Symposium on Avian Influenza
Publication Type: Abstract Only
Publication Acceptance Date: 1/2/2009
Publication Date: 4/5/2009
Citation: Hunt, H.D., Swayne, D.E. 2009. Major Histocompatibility Complex and Host Background Genes in Chickens Influence Resistance to High Pathogenicity Avian Influenza Virus [abstract]. 7th International Symposium on Avian Influenza, April 5-8, 2009, Athens, Georgia. p. 86.

Interpretive Summary:

Technical Abstract: The chicken’s major histocompatibility complex (MHC) haplotype has a profound influence on the resistance or susceptibility to certain pathogens such as B21 MHC haplotype confers resistance to Marek’s disease (MD). However, non-MHC genes are also important in disease resistance. For example, both lines 6 and 7 express the B2 MHC haplotype however line 6, but not line 7, is highly resistant to tumors induced by the Marek’s disease and avian leukosis viruses. Recently, field resistance of Thai indigenous chickens to H5N1 high pathogenicity avian influenza (HPAI) virus was attributed to B21 MHC haplotype while the B13 MHC haplotype was associated with high susceptibility. To determine the influence of the MHC haplotype on HPAI resistance, a series of MHC congenic white leghorn chicken lines (B2, B12, B13, B19 and B21) and lines with different background genes but with the same B2 MHC haplotype (Line 63 and 71) were intranasally challenged with 103 EID50 of H5N1 HPAI virus A/chicken/Indonesia/7/2003. None of the lines were completely resistant to lethal effects of the challenge as evident by mortality rates ranging from 40 to 100%. The B21 line had mortality of 40% and 70% and the B13 line had mortality of 60 and 100% in 2 separate trails. In addition, the mean death times varied greatly between groups, ranging from 3.7 to 6.9 days suggesting differences in disease pathogenesis. The data show that the MHC has some influence on the resistance to AI, but less than previously proposed, and non-MHC background genes may have a bigger influence on resistance than the MHC.