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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #207421
Title: Identification of a functional polymorphism at the Adipose Fatty Acid Binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: A path to follow

Author
item Ordovas, Jose

Submitted to: Nutrition Reviews
Publication Type: Review Article
Publication Acceptance Date: 1/1/2007
Publication Date: 3/1/2007
Citation: Ordovas, J.M. 2007. Identification of a functional polymorphism at the Adipose Fatty Acid Binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: A path to follow. Nutrition Reviews. 65(3):130-4.

Interpretive Summary:

Technical Abstract: Fatty acid binding proteins (FABPs) are proteins that reversibly bind fatty acids and other lipids. So far, 9 tissue-specific cytoplasmic FABPs have been identified. Adipose tissue FABP (FABP4) has been suggested to be a bridge between inflammation and other pathways related to the metabolic syndrome. In this regard, genetic variability at the FABP4 locus has been shown to be associated with plasma lipid levels, type 2 diabetes and coronary heart disease risk.