Skip to main content
ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #205383
Title: The Effect of Moderate Loss in Overweight and Obese Hyperlipidemic Women on Cholesterol Absorption, Synthesis and Turnover

Author
item SANTOSA, SYLVIA - MCGILL UNIVERSITY
item DEMONTY, ISABELLE - MCGILL UNIVERSITY
item Lichtenstein, Alice
item JONES, PETER - MCGILL UNIVERSITY

Submitted to: Annual Scientific Meeting NAASO, The Obesity Society
Publication Type: Abstract Only
Publication Acceptance Date: 6/1/2006
Publication Date: 10/24/2006
Citation: Santosa, S., Demonty, I., Lichtenstein, A.H., Jones, P.J. 2006. The Effect of Moderate Loss in Overweight and Obese Hyperlipidemic Women on Cholesterol Absorption, Synthesis and Turnover. Annual Scientific Meeting NAASO, The Obesity Society. October 20-24, 2006. Boston, MA. Abstract no. P0016.

Interpretive Summary:

Technical Abstract: Background: The effect of weight loss in women on cholesterol metabolism and the relationship between cholesterol absorption, synthesis and turnover (CAST) has not been examined. Objective: It was hypothesized that significant weight loss in overweigh and obese, hyperlipidemic women would lead to decreases in fractional synthesis rate (FSR) of cholesterol and increases in cholesterol absorption and turnover. Additionally, it was hypothesized that a relationship between changes in CAST variables would be found. Design: Thirty-five hyperlipidemic females (BMI 28-39 kg/m2_ 35-60 years participated in a six month weight loss trial. Weight loss resulted from a diet and exercise program that when combined produced a 30% energy deficit. CAST measurement was conducted between days 11 and 15 of the stabilization periods. Cholesterol absorption was measured using dual isotope ratio mass spectrometry comparing D7 labeled cholesterol administered IC and consumed C13 labeled cholesterol at h 6, 12, 24, 28 and 72 post injection. FSR was assessed using D7 labeled water incorporation at h72 and h96. Turnover of cholesterol pools was measured by D7 cholesterol decay between h12 and h72. Results: Average weight loss was 11.7+/-2.5 kg (P<0.0001). FSR decreased 3.84+/-1.58% (P=0.02). There were no changes in cholesterol absorption (2.98%+/-2.37%, P=0.22) nor turnover of cholesterol pools (6.07%+/-9.01%, {=0.51). Changes in weight did not correlate with either cholesterol absorption (r=-0.286; P=0.10), synthesis (r=0.120; P=0.49), or turnover (r=-0.191; P=0.30). No relationship was found between differences in CAST. Conclusion: Favorable lipid changes associated with moderate weight loss is primarily attributed to decreases in cholesterol synthesis and not to changes in cholesterol absorption and turnover.