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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #204468
Title: Apo-10'-lycopenoic acid suppresses lung cancer cell growth by activating retinoic acid receptor Beta in vitro, and inhibits lung tumorigenesis in vivo in the A/J mouse model

Author
item LIAN, FUZHI - HNRCA AT TUFTS
item Russell, Robert
item Smith, Donald
item Wang, Xiang-Dong

Submitted to: American Association of Cancer Research
Publication Type: Abstract Only
Publication Acceptance Date: 10/4/2006
Publication Date: 12/15/2006
Citation: Lian, F., Russell, R., Smith, D., Wang, X. Apo-10’-lycopenoic acid suppresses lung cancer cell growth by activating retinoic acid receptor Beta in vitro, and inhibits lung tumorigenesis in vivo in the A/J mouse model. 5th Annual American Association for Cancer Research International Conference: Frontiers in Cancer Prevention Research. Nov. 12-15, 2006, Boston, MA. Abstract No. A76.

Interpretive Summary:

Technical Abstract: Lycopene, which has been associated with a lower risk of a variety of cancers including lung cancer, can be cleaved enzymatically at its 9',10'-double bond and converted into apo-10'-lycopenoids both in vivo and in vitro. Here, we evaluated the potential chemopreventive effect of apo-10'-lycopenoic acid against lung tumorigenesis using the A/J mouse model. We show that the apo-10'-lycopenoic acid treatment significantly increased plasma concentrations of apo-10'-lycopenoic acid, and it significantly reduced lung tumor multiplicity (32.7 to 65.4% reduction) in A/J mice in a dose-dependent manner. We additionally demonstrate that apo-10'-lycopenoic acid inhibits the growth of NHBE normal human bronchial epithelial cells, BEAS-2B immortalized normal bronchial epithelial cells, and A549 non-small cell lung cancer cells. This inhibitory effect of apo-10'-lycopenoic acid was associated with decreased cyclin E and inhibition of cell cycle progression from G1 to S phase, and increased cell cycle regulators p21 and p27 protein levels. Furthermore, apo-10'-lycopenoic acid transactivated the retinoic acid receptor beta promoter and induced the expression of RAR-beta in these cells. Our findings suggest that apo-10'-lycopenoic acid is a potential chemopreventive agent against lung tumorigenesis, and its biological function can be mediated by the retinoid signaling pathway.