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Title: Mediterranean-style dietary pattern is associated with surrogate measures of insulin resistance in the Framingham Offspring Cohort

Author
item RUMAWAS, MARCELLA - HNRCA AT TUFTS UNIVERSITY
item MCKEOWN, NICOLA - HNRCA AT TUFTS UNIVERSITY
item ROGERS, GAIL - HNRCA AT TUFTS UNIVERSITY
item DWYER, JOHANNA - HNRCA AT TUFTS UNIVERSITY
item MEIGS, JAMES - MASS GENERAL HOSPITAL
item Jacques, Paul

Submitted to: Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 11/15/2006
Publication Date: 4/1/2007
Citation: Rumawas, M.E., Mckeown, N., Rogers, G., Dwyer, J.T., Meigs, J., Jacques, P. 2007. Mediterranean-style dietary pattern is associated with surrogate measures of insulin resistance in the Framingham Offspring Cohort. Experimental Biology/FASEB Journal. 21(5):6.

Interpretive Summary:

Technical Abstract: The traditional Mediterranean diet is associated with a lower risk of cardiovascular diseases (CVD). A diet score was developed to capture a Mediterranean-style dietary pattern in the Framingham Offspring Cohort. We examine the relationship between this diet score and markers of insulin resistance (fasting and 2-hr post-challenge plasma glucose and insulin and the homeostasis model assessment insulin resistance [HOMA-IR]) in 1238 men and 1505 women without diabetes. After adjustment for potential confounding factors, a higher diet score, reflecting greater adherence to Mediterranean-style dietary pattern, is associated with lower fasting plasma insulin concentrations (mean 35.0 vs 32.4 uU/mL in the lowest vs highest quartiles of diet score; P trend<0.01), 2-hr post-challenge plasma insulin (116 vs 98 uU/mL; P trend<0.01), HOMA-IR (8.4 vs 7.7; P trend<0.01) in subjects with abdominal obesity, but not in those with normal waist circumference. No association was found between diet score and fasting and 2-hr post-challenge plasma glucose. In individuals with greater abdominal adiposity, greater consistency with a Mediterranean-style dietary pattern was associated with better insulin sensitivity. Improved insulin sensitivity may be one mechanism by which adoption of Mediterranean-style dietary pattern may reduce risk of CVD. Supported by NIH/NHLBI Contract N01-HC-25195 and Grant NIA # 5R01-AG 16495.