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Title: The influence of thiazolidinediones on marbling in pigs: in vitro studies of muscle stromal-vascular cells from fetal and young pigs and in vivo studies of growing pigs

Author
item Hausman, Gary
item POULOS, SYLVIA - COCA COLA CO.
item PRINGLE, DEAN - UGA
item AZAIN, MIKE - UGA

Submitted to: Midwestern Section of the American Society of Animal Science
Publication Type: Abstract Only
Publication Acceptance Date: 10/25/2006
Publication Date: 3/21/2007
Citation: Hausman, G.J., Poulos, S.P., Pringle, D.T., Azain, M.J. 2007. The influence of thiazolidinediones on marbling in pigs: in vitro studies of muscle stromal-vascular cells from fetal and young pigs and in vivo studies of growing pigs[abstract]. Midwestern Section of the American Society of Animal Science. p. 87.

Interpretive Summary: none.

Technical Abstract: Thiazolidinediones (TZDs) are insulin sensitizing agents currently used for the treatment of type 2 diabetes and are widely used as adipogenic agents since they are ligands of PPAR', a key adipogenic transcription factor. In vitro studies of porcine S-V cells from semitendinosus muscles and adipose tissue show that thiazolidinediones have the potential to modify intramuscular or marbling adipogenesis. Muscle S-V cultures responded differentially to two thiazolidinediones, ie., ciglitazone and troglitazone whereas the response of adipose S-V cultures was independent of the thiazolidinedione. Therfore, intramuscular or marbling preadipocytes and adipose tissue preadipocytes may differ in regards to PPAR' affinity for TZDs. Fetal studies show that thiazolidinediones induce adipocyte development in muscle and adipose S-V cell cultures from very young fetuses. Furthermore, thiazolidinediones induces adipocyte development in fetal muscle and adipose S-V cultures much earlier than glucocorticoids. Gilts weighing approximately 70 kg were given 0, 4, or 12 mg rosiglitazone maleate, a thiazolidinedione orally, once daily, for 49 d then slaughtered using conventional techniques. Rosiglitazone did not affect overall food intake, body weight gain, feed conversion ratio or meat quality or texture. There were several significant changes in the fatty acid composition of tissues from rosiglitazone treated pigs. Rosiglitazone treatment did not influence carcass quality although there was a significant effect of slaughter d on meat quality. Nonetheless, the potential to alter energy metabolism in skeletal muscle using thiazolidinediones in pigs should be investigated further.