Author
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EJAZ, ASMA - TUFTS/HNRCA |
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CHOUDHARY, M. IQBAL - UNIV KARACHI, PAKISTAN |
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Submitted to: American Aging Association
Publication Type: Abstract Only Publication Acceptance Date: 6/2/2006 Publication Date: 6/2/2006 Citation: Ejaz, A., Choudhary, M. 2006. A new polyphenolics with strong radical scavenging activity. AGE. 28(1):32. Interpretive Summary: Technical Abstract: Oxidative stress and antioxidant are believed to be involved in aging process. Dietary antioxidant may delay the onset of aging and progression of chronic disease associated with aging. Herbal medicines are still the mainstay of about 75–80 percent of the world population. We have identified and isolated two new prenylated polyphenolic anthronoids, harunmadagascarins A and B, (Figure1) along with two known compounds from the stem bark of praying hands (Harungana madagascariensis), a common herbal medicine used in Europe and Africa for its antidiabetic and anti diarrhetic effects. The pure compounds have strong antioxidant activity in in vitro system as determined by scavenging of superoxide, DPPH and nitric oxide radicals as well as using TAS (total antioxidant status) and xanthine/ xanthine oxidase system. Our results indicate that these compounds possess significant activity. We found that harunmadagascarin A which is new compound has ten fold higher superoxide scavenging activity compared to synthetic antioxidant (3- t-B utyl-4-hydroxyanisloe ) and can quench NO and DPPH by more than 93-95 percent compared to di-hydroxyflavone. The in vitro evidence strongly suggests variety of health benefit such as cancer, inflammation and heart disease. These and other biological activity of these polyphenolic compounds are currently under investigation in our laboratory. This project was funded by HEC Pakistan. |
