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Title: EMERGENCE OF SUBGROUP J AVIAN LEUKOSIS VIRUS NEUTRALIZING ANTIBODY ESCAPE VARIANTS IN MEAT-TYPE CHICKENS INFECTED WITH VIRUS AT HATCH

Author
item PANDIRI, ARUN - MICHIGAN STATE UNIVERSITY
item REED, WILLIE - MICHIGAN STATE UNIVERSITY
item Silva, Robert
item Fadly, Aly

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 6/1/2006
Publication Date: 6/1/2006
Citation: Pandiri, A., Reed, W., Silva, R.F., Fadly, A.M. 2006. Emergence of subgroup J avian leukosis virus neutralizing antibody escape variants in meat-type chickens infected with virus at hatch [abstract]. American Association of Avian Pathologists and American Veterinary Medical Association Scientific Program. p. 73.

Interpretive Summary:

Technical Abstract: Infection of meat-type chickens at hatch with field isolates of Subgroup J avian leukosis virus (ALV J) results in a high incidence of chickens with persistent viremia even in the presence of neutralizing antibodies (NAb) against the inoculated parental virus (V+A+). The purpose of this study was to elucidate if the high incidence of V+A+ profile is due to the emergence of NAb escape mutants. Meat-type chickens were infected at hatch with an ALV J molecular clone (ADOL pR5-4). The emergence of NAb escape variants was evaluated by sequential autologous and heterologous virus neutralization (VN). Our results demonstrated that 88% of the chickens had V+A+ infection profile. All V+A+ chickens failed to neutralize autologous viruses demonstrating the emergence of NAb escape variants.