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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #183854
Title: THE EFFECTS OF THE DIETARY GLYCEMIC LOAD ON GLUCOSE-INSULIN DYNAMICS AND SYSTEMIC INFLAMMATION IN A 6-MONTH RANDOMIZED CALORIC RESTRICTION TRIAL

Author
item PITTAS, ANASTASSIOS - TUFTS/HNRCA
item DAS, SAI KRUPA - TUFTS/HNRCA
item HAJDUK, CHERYL - TUFTS/HNRCA
item GOLDEN, JULIE - TUFTS/HNRCA
item SALTZMAN, EDWARD - TUFTS/HNRCA
item STARK, PAUL - TUFTS-N.E. MEDICAL CTR
item ROBERTS, SUSAN - TUFTS/HNRCA
item GREENBERG, ANDREW - TUFTS/HNRCA

Submitted to: Obesity Research
Publication Type: Abstract Only
Publication Acceptance Date: 5/24/2005
Publication Date: 10/1/2005
Citation: Pittas, A.G., Das, S., Hajduk, C.L., Golden, J., Saltzman, E., Stark, P.C., Roberts, S.B., Greenberg, A.S. 2005. The effects of the dietary glycemic load on glucose-insulin dynamics and systemic inflammation in a 6-month randomized caloric restriction trial. Obesity Research. 13(Suppl):A199.

Interpretive Summary:

Technical Abstract: Insulin resistance, impaired beta cell function and systemic vascular inflammation are risk factors for glucose intolerance and type 2 diabetes. Diets low in glycemic load (GL) may improve these risk factors. Our objective was to compare the effects of two calorie-restricted diets that differ in glycemic load on glucose-insulin dynamics and systemic inflammation in healthy overweight adults. Randomized double-blind controlled feeding trial conducted over a 6-month period. Thirty-four healthy overweight (BMI 25-30 Kg/m**2), adults aged 20-42 years with normal glucose tolerance were recruited. Participants were randomly assigned to 30% caloric-restricted diets with high (HG) or low (LG) glycemic load. Participants received all their meals as outpatients for 6 months. Glucose-insulin dynamics during fasting and after a 75-gram glucose load and C-reactive protein (CRP) were measured at 0, 3 and 6 months. Thirty-two participants (mean age 34.6 years and mean BMI 27.7 kg/m**2) completed the 6-month intervention. Compared to baseline, fasting insulin, HOMA-IR, post-glucose load insulin at 30’ and incremental AUC-insulin improved in both groups. However, after adjusting for baseline values and weight change, no statistically significant differences were observed between the 2 groups in any measurement of glucose-insulin dynamics. In the LG group, 14 out of 16 participants exhibited declines in CRP vs. 9 out of 16 in the HG group. Results showed in a 6-month randomized controlled outpatient feeding trial in healthy overweight adults with normal glucose tolerance, there were no differences in glucose-insulin dynamics between the caloric-restricted HG and LG diets but declines in CRP were observed in the LG group.