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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #171962
Title: CALORIC RESTRICTION, WEIGHT LOSS AND DIETARY COMPOSITION

Author
item DAS, SAI KRUPA - TUFTS/HNRCA
item HAJDUK, CHERYL - TUFTS/HNRCA
item GOLDEN, JULIE - TUFTS/HNRCA
item PITTAS, ANASTASSIOS - TUFTS/HNRCA
item MCCRORY, MEGAN - TUFTS/HNRCA
item HADLEY, EVAN - NIH BETHESDA MD
item ROCHON, JAMES - DUKE CLINICAL RES INST
item FUSS, PAUL - TUFTS/HNRCA
item TYLER, STEPHANIE - TUFTS/HNRCA
item TSAY, MICHELLE - TUFTS/HNRCA
item CHEATHAM, RACHEL - TUFTS/HNRCA
item Saltzman, Edward
item Roberts, Susan

Submitted to: Obesity Research
Publication Type: Abstract Only
Publication Acceptance Date: 6/30/2004
Publication Date: 10/1/2004
Citation: Das, S., Hajduk, C., Golden, J., Pittas, A., Mccrory, M., Hadley, E., Rochon, J., Fuss, P., Tyler, S., Tsay, M., Cheatham, R., Saltzman, E., Roberts, S. 2004. Caloric restriction, weight loss and dietary composition [abstract]. Obesity Research. 12Suppl:A65-66.

Interpretive Summary:

Technical Abstract: Caloric restriction (CR) is the only intervention known to delay biological aging in animal models. Data presented here are part of an ongoing pilot study for a randomized clinical trial testing the feasibility of different CR regimens in overweight men and women. In this analysis we compared two different dietary regimens for their ability to promote body weight and fat losses over 1 year in the 34 overweight men and women studied to date (Mean±SD, BMI, 27.58±1.4kg/m**2; age, 35±6y). Both diets were consistent with current dietary recommendations, but one diet was a high carbohydrate, high glycemic index diet (P) and the other diet was a low carbohydrate, low glycemic index diet (G). Both diets were provided at 70% of ad libitum intake for 6 months, and then subjects were instructed to maintain the same regimen at home for a further 6 months. Fasting body weight was assessed at baseline and at weekly intervals throughout the study; body fatness was assessed using air displacement plethysmography at baseline, 1, 3, 6, 9 and 12 months. Mean weight loss (kg) for the P diet was 5.60±2.9 at 3mo; 7.36±4.6 at 6mo; and 8.45±4.6 at 12mo, and mean percent fat loss was 3.38±1.6 at 3mo; 5.63±3.3 at 6mo; and 5.62±3.3 at 12mo. Mean weight loss (kg) for the G diet was 5.54±2.3 at 3mo; 7.87±4.2 at 6mo; and 7.61±5.5 at 12mo, and mean percent fat loss was 3.99±2.1 at 3mo; 6.59±3.6 at 6mo; and 6.34±5.1 at 12mo. Analysis of variance was performed to compare differences in outcome variables between the P and G diets. No statistically significant differences were observed between the P and G diet for weight change, fat change or percent fat change at any of the time-points (P= 0.75-0.95; 0.43-0.99; 0.36-0.94). Based on this preliminary analysis of data from an ongoing trial, diets with a wide range of carbohydrate content and glycemic index appear to facilitate equivalent CR leading to sustained weight loss.