Page Banner

United States Department of Agriculture

Agricultural Research Service

Research Project: Application of Hormonal Biomarkers for Don-3-Glucoside Risk Assessment Project Number: 0500-00053-003-68
Project Type: Grant

Start Date: May 03, 2014
End Date: May 02, 2015

Objective:
Discern whether DON-3-G is sufficiently toxic to be included in the tolerable daily intake (TDI) for DON.

Approach:
Compare the effects of DON and DON-3-G on (1) [Ca2+]i elevation and CCK release in the cloned STC1 EEC model and (2) [Ca2+]i elevation and 5-HT secretion in cloned EC cell models. Compare the effects of DON and DON-3-G on (1)CCK release in primary murine I-cell-containing models, (2) PYY release in primary murine L-cell-containing models and (3) 5-HT secretion from intestinal whole mount preparations from mice and mink.

Last Modified: 11/25/2014
Footer Content Back to Top of Page