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United States Department of Agriculture

Agricultural Research Service

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Research Project: Agricultural Research Service Support to Cooperative Biological Engagement Program

Location: Foreign Animal Disease Research

Project Number: 8064-32000-057-54
Project Type: Interagency Reimbursable Agreement

Start Date: Sep 04, 2013
End Date: Mar 03, 2015

Objective:
ARS, PIADC will support the DTRA Cooperative Biological Engagement Program (CBEP) mission in a global partnership network targeting biosecurity research and capacity building in Sub-Saharan Africa. This collaborative effort supports research and development of countermeasures for surveillance and control of Foot-and-Mouth Disease (FMD) in Uganda. These objectives will be achieved through collaborative research projects between the USDA-ARS-PIADC and the Onderstepoort Veterinary Institute (OVI) of South Africa, Makerere University (MU) of Uganda, Ben Gurion University (BGU) of Israel, the Uganda Virus Research Institute (UVRI) and the University of California, Davis (UC Davis). Specific objectives include; 1. Novel countermeasures designed for the progressive control of Foot-and-Mouth Disease Virus (FMDV) in Uganda. 2. Development of improved diagnostic tools and a comprehensive surveillance program in Uganda.

Approach:
1. Novel countermeasures designed for the progressive control of Foot-and-Mouth Disease Virus (FMDV) in Uganda. A surveillance program of FMDV in Uganda will be conducted to identify the serotype, subtype and genetic makeup of FMD viruses circulating in the country. Serological studies will be conducted to determine the prevalence of circulating FMDV serotypes and to aid in antigen-matching studies. The information generated will be useful for the evaluation of current FMD control programs and the design of improved countermeasures in future control programs conducted by Ugandan veterinary services and other relevant organizations. Ugandan scientists will be trained in serological and molecular DNA techniques for the identification and characterization of endemic FMDV. 2. Development of improved diagnostic tools and a comprehensive surveillance program in Uganda. Capacity building efforts will include fundamental and applied research support to build collaborative ties with Ugandan scientists working on FMD. UVRI capacity will be enhanced through procurement of critical equipment, implementation of virus characterization and diagnostics processes as well as training provided by BGU collaborators for viral surveillance. BGU will train Ugandan scientists in molecular techniques utilizing camelid monoclonal antibodies. A surveillance program will be initiated in collaboration with the Ministry of Agriculture, Animal Industry and Fisheries (MAAIF) of Uganda which will include epidemiology and antigenic matching. Strain-specific diagnostic kits will be developed to identify locally circulating FMDV strains by BGU utilizing camel monoclonal antibodies. These diagnostic technologies and sustainable capabilities will be transferred to Ugandan veterinary services and other relevant organizations.

Last Modified: 12/22/2014
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