Association of Serum Vitamin D and Parathyroid Hormone Levels with Markers of Bone Health in HIV-Infected and Uninfected Children
Immunity and Disease Prevention Research Unit
Project Number: 5306-51530-018-60
Start Date: Apr 01, 2013
End Date: Jul 31, 2013
HIV infection causes inflammation and changes in nutrient metabolism that can affect development and remodeling of bone, particularly in growing children. The objective of the present study is to examine the contribution of vitamin D and calcium status to markers of bone mineral density in 479 HIV-positive and 267 HIV-negative infants from the Pediatric HIV/AIDS Cohort Study (PHACS).
Scientists at the USDA/ARS Western Human Nutrition Research Center will receive serum samples from the PHACS repository and will measure serum 25-hydroxy vitamin D, parathyroid hormone, calcium, phosphorus and creatinine concentrations. Results will be transmitted to the PHACS group. Data analysis will be carried out by a PHACS statistician working with PHACS investigators, Dr. Stephensen and Dr. Marta Van Loan of the ARS.