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United States Department of Agriculture

Agricultural Research Service

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Research Project: Foot-and-Mouth Disease Virus Diagnostic Test Development in Uganda

Location: Foreign Animal Disease Research

Project Number: 8064-32000-057-35
Project Type: General Cooperative Agreement

Start Date: Oct 01, 2013
End Date: Sep 30, 2014

Objective:
Foot-and-Mouth Disease (FMD) is a high priority re-emerging zoonotic transboundary disease with high economic implications which threatens animal health and livestock production in sub-Saharan African nations. This research project seeks to produce improved diagnostic reagents and tests for FMD surveillance tailored to Foot-and-Mouth Disease Virus (FMDV) types of the sub-Sahara territories in Africa. Specific objectives of this collaboration include: 1. Support capacity building program at the Uganda Virus Research Institute (UVRI) through viral characterization and diagnostic training and educational workshops. 2. Development of an inexpensive FMDV diagnostic kit based on camel monoclonal antibodies.

Approach:
1. Ben Gurion University (BGU) will provide training to UVRI staff in molecular techniques to aid in establishing a sustainable system for disease surveillance, epidemiology and databasing in Uganda. 2. BGU will provide UVRI staff training in molecular techniques of camel monoclonal antibody technology. Strain specific diagnostic tests for FMDV strains circulating in Uganda will be developed and produced at BGU with camel monoclonal antibodies. Strain diversity within and between the geographically distinct districts that are surveyed in Uganda will be determined by ARS, PIADC. Camel monoclonal antibodies will be isolated, and those specific to local FMDV strains, used in the production of ELISA based kits for surveillance in Uganda.

Last Modified: 10/21/2014
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