Location: Human Nutrition Research Center on Aging
Project Number: 1950-51000-070-22
Start Date: Jan 01, 2012
End Date: Dec 30, 2014
Rats will initially be purchased and maintained on a diet containing 2% tart cherry. Rats will then complete a battery of motor tests as well as cognitive testing in the Morris water maze. Following behavioral testing, areas of the rats’ brains, specific to learning, memory, and motor coordination, will be examined for a variety of inflammatory biomarkers using immunohistochemistry. Brains will also be evaluated for a variety of proteins involved in autophagy. Finally, we will determine whether the efficacies of cherry supplementation in the behavioral assays are associated with enhanced resistance to oxidative stressors and alterations in autophagy markers.