Start Date: Oct 01, 2011
End Date: Sep 30, 2015
Using a team approach we will address each sub-objective individually. AIV transmission will be evaluated by comparing routes of inoculation and by using several different species of bird to see they are susceptible to selected strains of AIV including the Asian highly pathogenic H5N1 lineage. Transmission to contact birds and measure of virus shed will also be tested. The approach to vaccine failure will be to vaccinate chickens with different immune statuses and after exposure to other common vaccines and pathogens to see the effect on vaccine efficacy. A further component will be to include challenge viruses which are not related to the vaccine strain. The immune response of ducks to AIV will be assessed by measuring the cell mediated immune response and other immunological and genetic factors in ducks which are exposed to the virus.