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United States Department of Agriculture

Agricultural Research Service

Research Project: DEOXYNIVALENOL: HUMAN METABOLISM OF KEY METABOLITES AND TOXICITY PREDICTORS Project Number: 0500-00053-003-42
Project Type: Grant

Start Date: Jul 07, 2011
End Date: Jul 06, 2013

Objective:
Develop approaches to optimize protection from DON in humans by altering the metabolism of this compound.

Approach:
By feeding DON-glucoside to mice, we propose to determine the metabolic fate of this compound by HPLC analysis. By incubating DON-glucoside with human feces and with mouse cecal contents and measuring DON contents by HPLC, we will be able to predict the extent to which this form of DON is likely to be converted to DON in humans and we will determine the usefulness of mouse models in simulating human gut microbial metabolism of this form of DON.

Last Modified: 10/24/2014
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