Start Date: Jan 02, 2011
End Date: Jan 01, 2013
ARS will acquire the basic knowledge of the effects of consuming proanthocyanidins in a pig model on epithelial cell function, changes in intestinal microbiome and function, and inhibition of bacterial pathogens on epithelial cell surfaces. This information will be used by both ARS and the Cooperator to jointly develop novel molecular and metabolomic techniques related to the study of proanthocyanidins. The Cooperator will evaluate the results of the analysis of phenolic metabolites in urine and use pure phenolic acids available as commercial standards and/or their mixtures to confirm the results from the urine assays.