Project Number: 1245-32000-098-09
Project Type: Reimbursable

Start Date: Jan 01, 2011
End Date: Apr 22, 2013

Objective:
Develop immunologic tools to enhance our understanding of swine immune system development and host responses to mucosal diseases. The cooperator is interested in preventing infectious disease and controlling their spread through development of effective therapeutics and vaccines for cattle and swine.

Approach:
Increase the understanding of how pigs responds to infection, by developing reagents that identify immune proteins [type I interferons (IFNs) and the IFN-alpha/beta receptor (IFNAR)] that regulate the early, or “innate” immune events. The COOPERATOR will assist in the development of similar reagents for cattle. Specifically, 19 reagents are identified by DHS and USDA-ARS as high priority reagents for US VIRN to develop to support foreign animal disease research programs (e.g., Foot and Mouth Disease; Rift Valley Fever; Classical Swine Fever).