Location: Foreign Animal Disease Research
Project Number: 1940-32000-057-28
Start Date: May 01, 2010
End Date: Apr 30, 2014
The bovine immune response to FMDV infection will be assessed through bioinformatics, high-throughput sequencing, peptide synthesis, proteomics and ultimately the major histocompatibility complex (MHC) tetramer technology or "tetramers". ARS will expand the present collaboration with the University of Vermont to achieve a more technically sophisticated and informative analysis of the immune response of cattle to FMDV infection and to vaccination with virus vectored FMD vaccines. This is made possible by utilizing the genetically defined animals from the University of Vermont's herds of Holstein cattle, or from the University of Vermont Dairy Center of Excellence cooperator herds.