Project Number: 5306-51000-003-14
Project Type: Trust

Start Date: Oct 01, 2010
End Date: Dec 31, 2013

Objective:
Objective: 1) Determine bone density; 2) determine bone metabolism; 3) evaluate calcium losses from the skeleton.

Approach:
Conduct a human study using 41Ca isotope tracer to quantify calcium losses directly from the skeleton in postmenopausal women. Sixteen healthy postmenopausal women will be enrolled and labeled with 41Ca tracer. Following tracer equilibration (~6mo.)women will be randomly assigned to 1 of 2 treatments: 1) 3-4 servings/d milk or 2) equivalent calcium citrate supplementation. Following first intervention women will cross-over to the other intervention. Urine and sera samples will be collected and analyzed for 41Ca excretion, bone metabolism markers, PTH and 25-(OH)vitamin D. Documents Trust with Dairy Research Institute. Log 41795.