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United States Department of Agriculture

Agricultural Research Service

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Research Project: PRRS HOST GENETICS CONSORTIUM: A PROPOSAL TO DEVELOP A CONSORTIUM TO STUDY THE ROLE OF HOST GENETICS AND RESISTANCE TO PRRSV

Location: Animal Parasitic Diseases

Project Number: 1245-32000-098-03
Project Type: Trust

Start Date: Nov 01, 2010
End Date: Nov 01, 2012

Objective:
The current specific aims are: 1) Use genotyping and phenotyping tools to determine if there are host genes that control resistance/susceptibility to porcine respiratory and the reproductive syndrome virus (PRRSV) infection; 2) Verify genetic variation in response to PRRSV, via improved health, survivability and growth; and 3) Identify relative importance of different phenotypes, and their heritability, that predict response to PRRSV infection.

Approach:
This is a multi-year project that is funded by a consortium representing NPB, USDA, universities and private companies. The consortium represents the first-of-its-kind approach to food animal infectious disease research. The objective of this cooperative research project is to assess the genetic basis of pig responses to porcine reproductive and respiratory syndrome virus (PRRSV) infection, an infection which causes pneumonia and growth retardation in pigs, affecting the respiratory mucosa. The project uses a Nursery Pig Model to assess pig resistance/susceptibility to primary PRRSV infection. Results from the first year have affirmed that there are genetic components involved in controlling the effectiveness of pig responses to PRRSV infection. By continuing these studies, the plan is to test a larger number (1,500 total over 4 years) of PRRSV infected pigs. Data collected, using a series of defined assays, stored samples for later work and collated data in the PHGC database will enable researchers to verify important genotypes and phenotypes that predict resistance, tolerance or susceptibility to PRRSV infection.

Last Modified: 7/28/2014
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