Start Date: Aug 01, 2010
End Date: Jul 31, 2013
A multidisciplinary biorefinery approach will be used to develop health-related and biobased co-products from plant cell wall polysaccharides in fruit and vegetable processing residues. Plant cell wall polysaccharides will be converted into biomedical materials for human tissue regeneration, cosmetic personal care products, carriers of bioactive substances for colon-specific delivery and to produce synbiotics, in which probiotic bacteria are encapsulated in a prebiotic. Plant cell wall oligosaccharide-based prebiotics will be isolated from agricultural processing residues rich in pectins and hemicelluloses. The hypothesis that prebiotics can selectively promote the growth of gut bacteria associated with lean tissue growth to potentially control obesity will be tested. Plant cell wall oligosaccharides will also be screened for biological activity such as preventing the adhesion of pathogenic bacteria to intestinal epithelial cells, immunomodulation, and induction of cancer cell apoptosis. Bioplastic composites will be designed with bacteriocins for control of food-borne pathogens with active packaging. Weight-bearing, light weight bioplastic composites will also be produced with construction and consumer product applications in mind. Update 2011: The light weight-bearing materials will be prepared from a group of biomass-oriented thermoplastics. Antimicrobials will be loaded by laminating a layer of polymer carrying antimicrobial actives onto the surface.