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United States Department of Agriculture

Agricultural Research Service

Research Project: Discovery and Reconstitution of Cross-Reactive Epitope Targets for H5 and H9 Avian Influenza

Location: Exotic and Emerging Avian Viral Diseases Research Unit

Project Number: 6612-32000-063-12
Project Type: Reimbursable

Start Date: Oct 01, 2010
End Date: Sep 30, 2014

Objective:
Identify and map highly conserved B-cell epitopes common to surface of H5 and H9 avian influenza (AI) and to test their suitability as homotypic or universal vaccine components.

Approach:
In this study, recombinant epitope mapping will be accomplished using sequence analysis of hemagglutinin genes of H5 and H9 avian influenza virus, and epitopes generated in comprehensive conformer-libraries to be displayed on filamentous bacteriophages. These epitopes will be selected for high evolutionary conservation and designed to elicit cross neutralization against diverse H5 and H9 avian influenza viruses. Most promising H5 and H9 epitopes will be used to immunize chickens and examine for ability to protect from H5 and H9 avian influenza virus challenge, respectively.

Last Modified: 8/22/2014
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