Start Date: Apr 17, 2009
End Date: Apr 16, 2014
The etiology and effective prevention of adult-onset weight gain remains poorly understood. In addition, there is little information on the effects of calorie restriction designed to reduce body weight on biological parameters related to aging. These questions will be addressed in a series of 4 studies designed to contribute to understanding the process of dietary change and effective methods for long-term weight control and their effects on long-term health. These will include a randomized controlled trial of human caloric restriction (CALERIE) examining the metabolic effects of a 25% reduction in energy intake for 2 years, a trial of low and high fat diets on weight change in relation to insulin secretion status, a genetic analysis of the heritability of body fat and related parameters in identical twins reared together or reared apart, and an intervention to examine the feasibility of changing dietary Disinhibition in free living individuals and the impact of such a change in body weight.