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United States Department of Agriculture

Agricultural Research Service

Research Project: DISCOVERY OF NEW INSECTICIDES AND REPELLENTS BY STRUCTURE-PROPERTY BASED MODELS

Location: Mosquito and Fly Research Unit

Project Number: 6036-32000-045-04
Project Type: Specific Cooperative Agreement

Start Date: Jun 15, 2009
End Date: Jun 15, 2014

Objective:
Predict chemical structures which will lead to the discovery of novel insecticides and repellents of mosquitoes and biting flies.

Approach:
Compounds with known insecticidal and repellent properties will be selected for modeling from the USDA database of over 30,000 tested chemicals. The subsets of chemicals will be modeled by sophisticated modern computer systems to develop quantitative structure-activity/property relationships (qsar/qspr) to define and improve mosquito and fly insecticides and repellents. Candidate insecticides and repellents will be obtained commercially, or synthesized as needed. Chemicals will be bioassayed for insecticidal and/or repellent properties.

Last Modified: 10/24/2014
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