Start Date: Sep 01, 2008
End Date: Jul 31, 2011
The overall goal of this application is the determination of the role of white-tailed deer as reservoirs of BVDV for domestic cattle. Our research objectives are: 1) Document the fetal pathogenesis resulting from BVDV infection of pregnant does. 2) Determine the ability of BVDV persistently infected deer to transmit BVDV to cattle or deer. To meet our research objectives we will infect pregnant white-tailed deer with BVDV in order to generate persistently infected (PI) fawns. To study transmission between cattle and deer we will expose BVDV naive cattle to fawns directly, to contaminated housing, or to contaminated feed.