Location: Foodborne Toxin Detection and Prevention
Project Number: 2030-42000-049-03
Start Date: May 16, 2014
End Date: Apr 30, 2016
SpinDx, a novel microflulidic diagnostic platform, will be used in the detection of high consequence pathogens and toxins. ARS developed monoclonal antibodies will be used in the immuno-detection of botulinum neurotoxins (BoNT) and other biological toxins. This new approach will be tested for efficacy and sensitivity in the "gold standard" mouse bioassays for toxin detection, as well as in ELISA detection formats. The collaborator will generate a prototype of the detector. ARS will test the prototype assay/instrument with spiked food samples and also with samples from mice intoxicated with toxins. We will compare the new assays using the prototype against gold standard assays, including the mouse BoNT assay or ELISA.