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United States Department of Agriculture

Agricultural Research Service

Research Project: Molecular, Cellular, and Regulatory Aspects of Nutrition During Development

Location: Children's Nutrition Research Center

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs - (Peer Reviewed Journal)
Guthrie, G., Kulkarni, M., Vlaardingerbroek, H., Stoll, B., Ng, K., Martin, C., Belmont, J., Hadsell, D.L., Heird, W., Newgard, C., Olutoye, O., Van Goudoever, J., Lauridsen, C., Schuchman, E., Burrin, D.G. 2016. Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs. Journal of Lipid Research. 57(8):1-18. doi:10.1194/jlr.M069526.
Enteral B-hydroxy-B-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs - (Peer Reviewed Journal)
Kao, M., Columbus, D.A., Suryawan, A., Steinhoff-Wagner, J., Hernandez-Garcia, A.D., Nguyen, H.V., Fiorotto, M., Davis, T. 2016. Enteral B-hydroxy-B-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 310(11): 1072-1084.
Determination of 7alpha-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs - (Peer Reviewed Journal)
Yun, C., Yin, T., Shatzer, K., Burrin, D.G., Cui, L., Tu, Y., Hu, M. 2016. Determination of 7alpha-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs. Journal of Chromatography B. 1025:76-82.
Microbial and metabolic signatures of necrotizing enterocolitis in formula-fed piglets - (Abstract Only)
Call, L., Stoll, B., Olutoye, O., Ajami, N., Petrosino, J., Wittke, A., Waworuntu, R., Berg, B., Burrin, D. 2016. Microbial and metabolic signatures of necrotizing enterocolitis in formula-fed piglets [abstract]. The Pediatric Academic Society Annual Conference, Session: Platform: Pediatric Nutrition, E-PAS2016:3140.2. April 30–May 3, 2016, Baltimore, Maryland. Available: https://www.pas-meeting.org/
Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs - (Peer Reviewed Journal)
Boutry, C., El-Kadi, S.W., Suryawan, A., Steinhoff-Wagner, J., Stoll, B., Orellana, R.A., Nguyen, H.V., Kimball, S.R., Fiorotto, M.L., Davis, T.A. 2016. Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 310(8):699-713.
Expression of apical Na(+)-L-glutamine co-transport activity, B(0)-system neutral amino acid co-transporter (B(0)AT1) and angiotensin-converting enzyme 2 along the jejunal crypt-villus axis in young pigs fed a liquid formula     Reprint Icon - (Peer Reviewed Journal)
Yang, C., Yang, X., Lackeyram, D., Rideout, T.C., Wang, Z., Stoll, B., Yin, Y., Burrin, D.G., Fan, M.Z. 2016. Expression of apical Na(+)-L-glutamine co-transport activity, B(0)-system neutral amino acid co-transporter (B(0)AT1) and angiotensin-converting enzyme 2 along the jejunal crypt-villus axis in young pigs fed a liquid formula. Amino Acids. 48(6):1491-1508.
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism - (Peer Reviewed Journal)
Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J.C., Tudawe, T., Seviour, E.G., San Lucas, F., Alvarez, H., Gupta, S., Maiti, S.N., Cooper, L., Peehl, D., Ram, P.T., Maitra, A., Nagrath, D. 2016. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. eLife. 5:e10250.
Trophic factors and regulation of gastrointestinal tract and liver development - (Book / Chapter)
Burrin, D.G. 2016. Trophic factors and regulation of gastrointestinal tract and liver development. In: Polin, R.A., Abman, S.H., and Fox, W.W. editors. Fetal and Neonatal Physiology, Section XIV Physiology of Gastrointestinal Tract in the Fetus and Neonate, 5th edition. Philadelphia PA: Elsevier Publishers. p. 853-858.
Interrelationships between glutamine and citrulline metabolism - (Review Article)
Marini, J.C. 2016. Interrelationships between glutamine and citrulline metabolism. Current Opinion in Clinical Nutrition and Metabolic Care. 19(1):62-66.
The ERa-PI3K cascade in proopiomelanocortin progenitor neurons regulates feeding and glucose balance in female mice - (Peer Reviewed Journal)
Zhu, L., Xu, P., Cao, X., Yang, Y., Hinton, A., Xia, Y., Saito, K., Yan, X., Zou, F., Ding, H., Wang, C., Yan, C., Pradip, S., Khan, S.A., Zhao, J., Fukuda, M., Tong, Q., Clegg, D.J., Chan, L., Xu, Y. 2015. The ERa-PI3K cascade in proopiomelanocortin progenitor neurons regulates feeding and glucose balance in female mice. Endocrinology. 156(12):4474-4491.
Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs - (Peer Reviewed Journal)
Columbus, D.A., Steinhoff-Wagner, J., Suryawan, A., Nguyen, H.V., Hernandez-Garcia, A., Fiorotto, M.L., Davis, T.A. 2015. Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs. American Journal of Physiology - Endocrinology and Metabolism. 309(6):601-610.
Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs - (Peer Reviewed Journal)
Marjarin, R., Columbus, D.A., Suryawan, A., Hernandez-Garcia, A.D., Hoang, N., Fiorotto, M.L., Davis, T.A. 2015. Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs. Amino Acids. 48(1):257-267.
FABP4-Cre mediated expression of constitutively active ChREBP protects against obesity - (Peer Reviewed Journal)
Nuotio-Antar, A.M., Poungvarin, N., Li, M., Schupp, M., Mohammad, M., Gerard, S., Zou, F., Chan, L. 2015. FABP4-Cre mediated expression of constitutively active ChREBP protects against obesity. Endocrinology. 11:4020-4032.
Enteral obeticholic acid prevents hepatic cholestasis in total parenteral nutrition-fed neonatal pigs - (Abstract Only)
Burrin, D.G., Jiang, Y., Fang, Z., Stoll, B., Guthrie, G.J., Wang, H., Ipharraguerre, I.R., Pastor, J.J. 2015. Enteral obeticholic acid prevents hepatic cholestasis in total parenteral nutrition-fed neonatal pigs [abstract]. Hepatology. Paper No. 194, 62(1)Suppl:307A.
Enteral obeticholic acid promotes intestinal growth in total parenteral nutrition fed neonatal pigs - (Abstract Only)
Jiang, Y., Fang, Z., Stoll, B., Guthrie, G.J., Holst, J., Hartmann, B., Burrin, D.G. 2015. Enteral obeticholic acid promotes intestinal growth in total parenteral nutrition fed neonatal pigs [abstract]. Hepatology. Paper No. 1689. 62(1)Suppl:1032A.
The glucose sensor ChREBP links de-novo lipogenesis to PPARgamma activity and adipocyte differentiation - (Peer Reviewed Journal)
Witte, N., Muenzner, M., Rietscher, J., Knauer, M., Heidenreich, S., Nuotio-Antar, A.M., Graef, F.A., Fedders, R., Tokachov, A., Goehring, I., Schupp, M. 2015. The glucose sensor ChREBP links de-novo lipogenesis to PPARgamma activity and adipocyte differentiation. Endocrinology. http://dx.doi.org/10.1210/EN.2015-1209.
Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs - (Peer Reviewed Journal)
Shen, R.L., Thymann, T., Ostergaard, M.V., Stoy, A.C., Krych, L., Nielsen, D.S., Lauridsen, C., Hartmann, B., Holst, J.J., Burrin, D.G., Sanglid, P.T. 2015. Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs. American Journal of Physiology - Gastrointestinal and Liver Physiology. 309(5):G310-G323.
Circadian dysfunction induces leptin resistance in mice - (Peer Reviewed Journal)
Kettner, N.M., Mayo, S.A., Hua, J., Choogon, L., Moore, D.L., Fu, L. 2015. Circadian dysfunction induces leptin resistance in mice. Cell Metabolism. 22:1-12.
Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice - (Peer Reviewed Journal)
Buras, E., Yang, L., Saha, P., Kim, J., Mehta, P., Yang, Y., Hilsenbeck, S., Kojima, H., Chen, W., Smith, C.W., Chan, L. 2015. Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. Federation of American Societies for Experimental Biology Conference. 29:3537-3548.
Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis - (Peer Reviewed Journal)
Nagy-Szakal, D., Mir, S., Harris, R., Dowd, S., Yamada, T., Lacorazza, H., Tatevian, N., Smith, C., De Zoeten, E., Klein, J., Kellermayer, R. 2015. Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis. Journal of Federation of American Societies for Experimental Biology. 29:3151-3159.
Formula carbohydrate content differentially shapes the microbial community patterns and NEC incidence in premature pigs - (Abstract Only)
Burrin, D.G., Call, L., Stoll, B., Akinkuotu, A., Olutoye, O., Ajami, N., Petrosino, J., Wittke, A. 2015. Formula carbohydrate content differentially shapes the microbial community patterns and NEC incidence in premature pigs [abstract]. Proceedings of the 48th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, May 6-9, 2015, Amsterdam, The Netherlands, 60(Suppl. 1):748-749.
Enteral obeticholic acid prevents PNALD and promotes intestinal growth in TPN fed neonatal piglets - (Abstract Only)
Stoll, B., Jiang, Y., Fang, Z., Wang, H., Guthrie, G., Burrin, D.G. 2015. Enteral obeticholic acid prevents PNALD and promotes intestinal growth in TPN fed neonatal piglets [abstract]. Proceedings of the 48th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, May 6-9, 2015, Amsterdam, The Netherlands, 60(Suppl. 1):64.
Importance of Animals in Agricultural Sustainability and Food Security - (Other)
Reynolds, L.P., Wulster-Radcliffe, M.C., Aaron, D.K., Davis, T.A. 2015. Importance of Animals in Agricultural Sustainability and Food Security. Journal of Nutrition. 145(7):1377-1379.
Glutamine supplementation, citrulline production, and de novo arginine synthesis: Is there a relation? - (Other)
Ligthart-Melis, G.C., Marini, J.C., Engelen, M.P., Deutz, N.E. 2015. Glutamine supplementation, citrulline production, and de novo arginine synthesis: Is there a relation? [Letter to the Editor]. American Journal of Clinical Nutrition. 101(4):890-892.
Low abdominal NIRS values and elevated plasma intestinal fatty acid-binding protein in a premature piglet model of necrotizing enterocolitis - (Peer Reviewed Journal)
Zamora, I.J., Stoll, B., Ethun, C.G., Sheikh, F., Yu, L., Burrin, D.G., Brandt, M.L., Olutoye, O.O. 2015. Low abdominal NIRS values and elevated plasma intestinal fatty acid-binding protein in a premature piglet model of necrotizing enterocolitis. PLoS One. 10(6):e0125437. doi:10.1371/journal.pone.0125437.
Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice - (Peer Reviewed Journal)
Marini, J.C., Agarwal, U., Didelija, I. 2015. Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice. Journal of Nutrition. 145(6):1227-1231.
Defining meal requirements for protein to optimize metabolic roles of amino acids - (Peer Reviewed Journal)
Layman, D.K., Anthony, T.G., Rasmussen, B.B., Adams, S.H., Lynch, C.J., Brinkworth, G.D., Davis, T.A. 2015. Defining meal requirements for protein to optimize metabolic roles of amino acids. American Journal of Clinical Nutrition. 101(Suppl):1330S-1338S.
Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice - (Peer Reviewed Journal)
Marini, J.C., Didelija, I. 2015. Arginine depletion by arginine deiminase does not affect whole protein metabolism or muscle fractional protein synthesis rate in mice. PLoS One. 10(3):e0119801. doi:10.1371/journal.pone.0119801.
Platelet recruitment promotes keratocyte repopulation following corneal epithelial abrasion in the mouse - (Peer Reviewed Journal)
Lam, F.W., Phillips, J., Landry, P., Magadi, S., Smith, C., Rumbaut, R.E., Burns, A.R. 2015. Platelet recruitment promotes keratocyte repopulation following corneal epithelial abrasion in the mouse. PLoS One. 29:3151-3159.
Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultramobile ambulatory total parenteral nutrition piglet model - (Peer Reviewed Journal)
Jain, A.K., Wen, J.X., Arora, S., Blomenkamp, K.S., Rodrigues, J., Blaufuss, T.A., Liou, V., Burrin, D.G., Long, J.P., Teckman, J.H. 2014. Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultramobile ambulatory total parenteral nutrition piglet model. Nutrition Research. 35(2):169-174.
Vitamin E in new-generation lipid emulsions protects against parenteral nutrition-associated liver disease in parenteral nutrition-fed preterm pigs - (Peer Reviewed Journal)
Ng, K., Stoll, B., Chacko, S., Saenz De Pipaon, M., Lauridsen, C., Gray, M., Squires, E., Marini, J.C., Zamora, I.J., Olutoye, O.O., Burrin, D.G. 2015. Vitamin E in new-generation lipid emulsions protects against parenteral nutrition-associated liver disease in parenteral nutrition-fed preterm pigs. Journal of Parenteral and Enteral Nutrition. DOI: 10.1177/0148607114567900.
Neuroanatomy and transgenic technologies - (Other)
Jackson, A.C., Liu, C., Fukuda, M., Gautron, L. 2015. Neuroanatomy and transgenic technologies. Frontiers in Neuroanatomy. 8:157.
Bolus vs. continuous feeding to optimize anabolism in neonates - (Peer Reviewed Journal)
Davis, T.A., Fiorotto, M.L., Suryawan, A. 2015. Bolus vs. continuous feeding to optimize anabolism in neonates. Current Opinion in Clinical Nutrition and Metabolic Care. 18(1):102-108.
Mechanisms of nutrient sensing - (Book / Chapter)
Burrin, D.G., Davis, T.A. 2014. Mechanisms of nutrient sensing. In: Ross, A.C., Caballero, B., Cousins, R.J., Tucker, K.L., Ziegler T.R., editors. Modern Nutrition in Health and Disease. 11th edition. Baltimore, MD: Lippincott Williams & Wilkens. p. 626-632.
Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: Translational relevance and challenges - (Review Article)
Sanglid, P., Ney, D.M., Sigalet, D.L., Vegge, A., Burrin, D.G. 2014. Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: Translational relevance and challenges. American Journal of Physiology - Gastrointestinal and Liver Physiology. 307(12):G1147-G1168.
Enteral leucine and protein synthesis in skeletal and cardiac muscle - (Book / Chapter)
Suryawan, A., Davis, T.A. 2015. Enteral leucine and protein synthesis in skeletal and cardiac muscle. In: Rajendram, R., Preedy, V.R, Patel, V.B., editors. Branched Chain Amino Acids in Clinical Nutrition. 1st edition. New York, NY: Springer. p. 197-210.
Gamma delta T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice - (Peer Reviewed Journal)
Mehta, P., Nuotio-Antar, A.M., Smith, C. 2015. Gamma delta T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice. Journal of Leukocyte Biology. 97:121-134.
Delayed initiation but not gradual advancement of enteral formula feeding reduces the incidence of necrotizing enterocolitis (NEC) in preterm pigs - (Peer Reviewed Journal)
Ghoneim, N., Bauchart-Thevret, C., Oosterloo, B., Stoll, B., Kulkarni, M., Saenz De Pipaon, M., Zamora, I.J., Olutoye, O.O., Berg, B., Wittke, A., Burrin, D.G. 2014. Delayed initiation but not gradual advancement of enteral formula feeding reduces the incidence of necrotizing enterocolitis (NEC) in preterm pigs. PLoS One. 9(9):e106888. doi: 10.1371/journal.pone.0106888.
New generation lipid emulsion protects against LPS-induced brain inflammation in pemature piglets - (Abstract Only)
Guthrie, G., Hodges, B., Martin, C.R., Stoll, B., Olutoye, O.O., Freedman, S.D., Burrin, D.G. 2014. New generation lipid emulsion protects against LPS-induced brain inflammation in pemature piglets. Archives of Disease in Childhood. 99(Suppl 2):PS-341a, A235.
Metabolomic determinants of necrotizing enterocolitis in preterm piglets - (Abstract Only)
Call, L., Stoll, B., Garcia, S., Bauchart-Thevret, C., Donnelly, J., Sheikh, F., Akinkuotu, A., Olutoye, O.O., Wittke, A., Burrin, D.G. 2014. Metabolomic determinants of necrotizing enterocolitis in preterm piglets. Archives of Disease in Childhood. 99(Suppl 2):PO-0607b, A451.
Extrarenal citrulline disposal in mice with impaired renal function - (Peer Reviewed Journal)
Marini, J.C., Didelija, I.C., Fiorotto, M.L. 2014. Extrarenal citrulline disposal in mice with impaired renal function. American Journal of Physiology - Renal Physiology. 307(6):F660-F665.
Abdominal near-infrared spectroscopy measurements are lower in preterm infants at risk for necrotizing enterocolitis - (Peer Reviewed Journal)
Patel, A.K., Lazar, D.A., Burrin, D.G., Smith, E., Magliaro, T.J., Stark, A.R., Brandt, M.L., Zamora, I.J., Sheikh, F., Akinkuotu, A.C., Olutoye, O.O. 2014. Abdominal near-infrared spectroscopy measurements are lower in preterm infants at risk for necrotizing enterocolitis. Pediatric Critical Care Medicine. 15(8):735-741.
Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis - (Peer Reviewed Journal)
Williams, K.W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E.D., Deng, Z., Gao, Y., Liu, T., Sohn, J., Jia, L., Fujikawa, T., Kohno, D., Scott, M.M., Lee, S., Lee, C.E., Sun, K., Chang, Y., Scherer, P.E., Elmquist, J.K. 2014. Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis. Cell Metabolism. 20(3):471-482.
Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance - (Peer Reviewed Journal)
Jia, L., Vianna, C.R., Fukuda, M., Berglund, E.D., Liu, C., Tao, C., Sun, K., Liu, T., Harper, M.J., Lee, C.E., Lee, S., Scherer, P.E., Elmquist, J.K. 2014. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance. Nature Communications. 5:3878.
Circadian gene variants in cancer - (Review Article)
Kettner, N.M., Katchy, C.A., Fu, L. 2014. Circadian gene variants in cancer. Annals of Medicine. 46:208-220.
Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution - (Peer Reviewed Journal)
Mamrosh, J.L., Lee, J., Wagner, M., Stambrook, P.J., Whitby, R.J., Sifers, R.N., Wu, S., Tsai, M., Demayo, F.J., Moore, D.D. 2014. Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. eLife. 3:e01694.
Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice - (Peer Reviewed Journal)
Asterholm, I.W., Rutkowski, J.M., Fujikawa, T., Cho, Y.R., Fukuda, M., Tao, C., Wang, Z.V., Gupta, R.K., Elmquist, J.K., Scherer, P.E. 2014. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 57(6):1209-1218.
AKI after conditional and kidney-specific knockdown of Stanniocalcin-1 - (Peer Reviewed Journal)
Huang, L., Belousova, T., Szu-Chin Pan, J., Du, J., Ju, H., Lu, L., Zhang, P., Truong, L.D., Nuotio-Antar, A., Sheikh-Hamad, D. 2014. AKI after conditional and kidney-specific knockdown of Stanniocalcin-1. Journal of the American Society of Nephrology. 2(10):2303-2315.
Intergrin-dependent neutrophil migration in the injured mouse cornea - (Peer Reviewed Journal)
Hanlon, S., Smith, C., Sauter, M., Burns, A. 2014. Intergrin-dependent neutrophil migration in the injured mouse cornea. Experimental Eye Research. 120:61-70.
Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of beta-hydroxy-beta-methylbutyrate - (Peer Reviewed Journal)
Wheatley, S.M., El-Kadi, S.W., Suryawan, A., Boutry, C., Orellana, R.A., Nguyen, H.V., Davis, S.R., Davis, T.A. 2014. Protein synthesis in skeletal muscle of neonates is enhanced by administration of beta-hydroxy-beta-methylbutyrate. American Journal of Physiology - Endocrinology and Metabolism. 306:E91-E99.
Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of Beta-hydroxy-Beta-methylbutyrate - (Peer Reviewed Journal)
Wheatley, S.M., El-Kadi, S.W., Suryawan, A., Boutry, C., Orellana, R.A., Nguyen, H.V., Davis, S.R., Davis, T.A. 2014. Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of Beta-hydroxy-Beta-methylbutyrate. American Journal of Physiology - Endocrinology and Metabolism. 306(1):E91-99.
Last Modified: 8/23/2016
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