Location: Animal Parasitic Diseases
Project Number: 8042-32000-090-19
Start Date: Jul 01, 2013
End Date: Jun 30, 2014
The USDA is uniquely positioned to perform large-scale studies, survival studies not performed elsewhere, and studies with oocysts/sporozoites not performed elsewhere. The ability of immunotherapy to protect mice against oocyst induced disease will be tested in mice using oral inoculation with oocysts obtained from Type I, II III, and atypical strains in the Dubey Laboratory. Clinical, histologic, serologic, and immunologic parameters will be used to evaluate the efficacy of the vaccines for protection. Vaccination procedures will be optimized with different epitope preparations and appropriate adjuvant and delivery systems in HLA transgenic mice.