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United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: Plasma Kinetics and Tissue Residues after Label and Extralabel Administration of Flunixin Meglumine to Cull Dairy Cows

Location: Animal Metabolism-Agricultural Chemicals Research

Project Number: 5442-32000-014-11
Project Type: Specific Cooperative Agreement

Start Date: Sep 01, 2013
End Date: Sep 30, 2015

Objective:
To determine the plasma kinetics and tissue and milk residues of flunixin after IV (label) and IM administration of flunixin to healthy and endotoxin-challenged cull dairy cows.

Approach:
A residue depletion study will be conducted in twenty normal and endotoxin-treated dairy cattle dosed intramuscularly (off-label) or intravenously (label use) with flunixin meglumine. Animals will be dosed with flunixin for three consecutive days with blood, milk, saliva, and urine samples being serially removed for flunixin analysis. Ninety-six hours after the last flunixin administration, cows will be euthanized and edible and non-edible tissues will be collected for the determination of flunixin tissue concentrations.

Last Modified: 4/23/2014
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