SEPPIC Adjuvants for Immune Mechanisms
Animal Biosciences and Biotechnology Laboratory
Project Number: 1245-32000-097-19
Start Date: Jan 01, 2013
End Date: Dec 30, 2017
SEPPIC is an adjuvant company which sells various adjuvants (agent that boost immunity) for vaccine formulation for humans, livestock, poultry, and fish. The major objective of this study is to investigate commercially available SEPPIC's adjuvants for their immune boosting effect on the immunization of broiler chickens using Clostridium perfringens proteins. ARS will use necrotic enteritis (NE) disease model that was developed by ARS to evaluate the effects of adjuvant-protein formulations and to study immune mechanisms.
SEPPIC's commercially available adjuvants will be mixed with Clostridium and coccidia proteins at ARS and injected orally or subcutaneously to broiler chickens. Immune parameters to be assessed include serum and intestinal antibodies, lymphocyte proliferation and cytokine response as well as gut lesions and body weights.