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United States Department of Agriculture

Agricultural Research Service

Research Project: Developing Genetic Biotechnologies for Increased Food Animal Production, Including Novel Antimicrobials for Improved Health & Product Safety

Location: Animal Biosciences and Biotechnology Laboratory

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

A thermophilic phage endolysin fusion to a Clostridium perfringens-specific cell wall binding domain creates an anti-clostridium antimicrobial with improved thermostability     Reprint Icon - (Peer Reviewed Journal)
Swift, S., Seal, B.S., Garrish, J.K., Oakley, B., Yeh, H., Heitt, K., Woolsey, R., Schegg, K.M., Line, E.J., Donovan, D.M. 2015. A thermophilic phage endolysin fusion to a Clostridium perfringens-specific cell wall binding domain creates an anti-clostridium antimicrobial with improved thermostability. Viruses and Bacteriophages. 7(6):3019-34.
Bacteriophage phi11 lysin: physicochemical characterization and comparison with phage phi80a lysin - (Peer Reviewed Journal)
Filatova, L.Y., Donovan, D.M., Foster Frey, J.A., Pugachev, V.G., Dmitrieva, N.F., Chubar, T.A., Klyachko, N.L., Kabanov, A.V. 2015. Bacteriophage phi11 lysin: physicochemical characterization and comparison with phage phi80a lysin. Enzyme and Microbial Technology. 73-74:51-58. doi: 10.1016/j.enzmictec.2015.03.005.
Magentic Cell labeling of primary and stem cell-derived pig hepatocytes for MRI-based cell tracking of heptocytes transplantation - (Peer Reviewed Journal)
Roach, D.R., Garrett, W.M., Welch, G.R., Caperna, T.J., Talbot, N.C., Shapiro, E.M. 2015. Magentic Cell labeling of primary and stem cell-derived pig hepatocytes for MRI-based cell tracking of heptocytes transplantation. PLoS One. 10(4):e0123282. doi: 10.1371/journal.pone.0123282. eCollection 2015.
Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing - (Peer Reviewed Journal)
Talbot, N.C., Aravalli, R.N., Steer, C.J. 2015. Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing. Hepatology. 21(7):2011-29.
Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection - (Peer Reviewed Journal)
Schmelcher, M., Shen, Y., Nelson, D.C., Eugster, M.R., Eichenseher, F., Hanke, D.C., Loessner, M.J., Dong, S., Pritchard, D.G., Lee, J.C., Becker, S.C., Donovan, D.M. 2015. Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection. Antimicrobial Chemotherapy. 2015 Jan 27, pii: dku552.
Antibacterial and antibiofilm surfaces through Polydopamine-assisted immobilization of Lysostaphin as an antibacterial enzyme - (Peer Reviewed Journal)
Yeroslavsky, G., Foster Frey, J.A., Donovan, D.M., Rahimipour, S. 2014. Antibacterial and Antibiofilm Surfaces through Polydopamine-Assisted Immobilization of Lysostaphin as an Antibacterial Enzyme. Langmuir. Langmuir, 2015, 31 (3), pp 1064–1073.
Lytic activity of the staphylolytic Twort phage endolysin CHAP domain is enhanced by the SH3b cell wall binding domain - (Peer Reviewed Journal)
Becker, S.C., Korobova, O., Schischkova, N., Kopylov, P., Donovan, D.M., Abaev, I. 2014. Lytic activity of the staphylolytic Twort phage endolysin CHAP domain is enhanced by the SH3b cell wall binding domain. FEMS Microbiology Letters. 362(1):1-8.
Can endolysin expressing yeast protect ethanolic fermentations and replace antibiotics in animal feed? - (Abstract Only)
(21-May-14)
Triple-acting antimicrobial treatment for drug-resistant and intracellular Staphylococcus aureus. - (Abstract Only)
(21-May-14)
Convergent evolution in peptidoglycan cut sites of phage endolysins protecting mice from methicillin-resistant Staphylococcus aureus septicemia - (Abstract Only)
(21-May-14)
Identification and characterization of peptidoglycan hydrolase constructs with activity in cow milk as potential antimicrobials for treatment of staphylococcal bovine mastitis - (Abstract Only)
(21-May-14)
Generation of induced pluripotent stem cells from the pig - (Abstract Only)
(16-May-14)
Intravitreal injection of a chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis - (Peer Reviewed Journal)
Singh, P.K., Donovan, D.M., Kumar, A. 2014. Intravitreal injection of a chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis. Antimicrobial Chemotherapy.
Triple-acting antimicrobial treatment for drug-resistant and intracellular Staphylococcus aureus - (Abstract Only)
(28-Apr-14)
Alternatives to antibiotics: overview and engineered peptidoglycan hydrolases that reduce resistance development - (Abstract Only)
(24-Apr-14)
Proteome array identification of bioactive soluble proteins/peptides in matrigel; relevance to stem cell responses - (Peer Reviewed Journal)
(03-Apr-14)
Triple-acting antimicrobial treatment for drug-resistant and intracellular Staphylococcus aureus - (Abstract Only)
(01-Apr-14)
Phage lytic enzymes targeting streptococci - (Abstract Only)
(01-Apr-14)
Triple-acting Peptidoglycan hydrolase treatment for drug-resistant and intracellular Staphylococcus aureus - (Abstract Only)
(18-Mar-14)
An investigation of the structure and function of antistaphylococcal endolysins using kinetic methods - (Other)
Filatova, L., Donovan, D.M., Becker, S.C., Kabanov, A., Klyachko, N.L. 2014. An investigation of the structure and function of antistaphylococcal endolysins using kinetic methods. Moscow University Chemistry Bulletin. Vol. 69, No.3, pp.107-111.
Physicochemical characterization of Staphylococcus aureus-lysing LysK enzyme in complexes with polycationic - (Peer Reviewed Journal)
Filatova, L.Y., Donovan, D.M., Becker, S.C., Lebedev, D.N., Priyma, A.D., Koudriachova, E.V., Kabanov, A.V., Klyachko, N.L. 2013. Physicochemical characterization of Staphylococcus aureus-lysing LysK enzyme in complexes with polycationic. Biochimie. 95(9):1689-1996.
Undetectable bacterial resistance to phage lytic proteins from the Staphylococcus aureus bacteriophage vB_SauS-phiIPLA88 - (Peer Reviewed Journal)
Rodriguez-Rubio, L., Martinez, B., Rodriguez, A., Donovan, D.M., Götz, F., García, P. 2013. Undetectable bacterial resistance to phage lytic proteins from the Staphylococcus aureus bacteriophage vB_SauS-phiIPLA88. PLoS One. 8(5):e64671.
Bacteriophage-encoded lytic enzymes control growth of contaminating Lactobacillus found in fuel ethanol fermentations - (Peer Reviewed Journal)
Roach, D.R., Khatibi, P.A., Bischoff, K.M., Hughes, S.R., Donovan, D.M. 2013. Bacteriophage-encoded lytic enzymes control growth of contaminating Lactobacillus found in fuel ethanol fermentations. Biotechnology for Biofuels. 6(1):20.
Last Modified: 7/3/2015
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