1a.Objectives (from AD-416):
Potatoes are widely used throughout the world as a staple food. Recently, their role in the diet has been questioned, particularly in relation to glycemia and the risk of developing type 2 diabetes mellitus. We challenge that notion, and propose that consuming potatoes as part of a mixed meal can be a healthy adjunct to lifestyle modification for reducing risk markers of cardiometabolic disease. In order to test this hypothesis, we will carry out a controlled feeding trial with overweight/obese volunteers in which we will compare potatoes containing high or low amounts of resistant starch to other commonly consumed carbohydrate sources in a lifestyle modification program. We will assess the effects of those treatments on biomarkers of cardiometabolic risk: blood glucose responses, insulin sensitivity, lipids and inflammatory markers. These studies will be carried out at the USDA Grand Forks Human Nutrition Research Center (GFHNRC).
1b.Approach (from AD-416):
Our primary objective is to compare the cardiometabolic effects of potato consumption to those of commonly consumed carbohydrate sources on glucose tolerance in overweight and obese, glucose intolerant men and women participating in a lifestyle intervention program. We hypothesize that consumption of potatoes is a healthy adjunct to lifestyle intervention in overweight and obese glucose intolerant adults. Our specific aims include: (1) to evaluate of the effects of the consumption of potatoes (high or low resistant starch) vs. commonly consumed carbohydrate sources on glucose tolerance; and (2) to determine the extent to which potato consumption alters markers of lipid metabolism and inflammation in the context of a lifestyle intervention program.
The 8-week group weight management program is being developed. Analysis of the resistant starch content of the potato products is currently being done and these data will be used to develop the recipes for the intervention. The IRB application is under development. Subject recruitment has not yet started. The study schedule is right on target. No data are yet available.