Location: Foreign Animal Disease Research
Project Number: 8064-32000-056-14
Start Date: Jul 01, 2012
End Date: Dec 31, 2014
1. USDA-ARS will identify and provide selected recombinant African Swine Fever Virus (ASFV) and Classical Swine Fever Virus (CSFV) genes which have known immunogenetic properties to the Univeristy of Wisconsin (UW). UW will manipulate the Ankara Virus (APV), introducing the recombinant ASFV/ CSFV genes, resulting in a mutated virus which, when replicated will express proteins encoded by the ASFV/ CSFV genes. 2. Resulting mutated viruses will be tested in swine in vivo by USDA-ARS. Challenge studies against and the presence of ASFV/CSFV-related signed and mortality rates will be assessed. Upon successful trails utilizing homologous virus, further studies will be conducted utilizing additional strains.