Production and Efficacy Testing of Bm86-Texas Anti-Tick Vaccine for the Cattle Fever Tick Eradication Program
Tick and Biting Fly Research
2013 Annual Report
1a.Objectives (from AD-416):
Expedite production and laboratory efficacy testing of a novel anti-tick vaccine formulation as a tool for integrated approaches to keep the U.S. free of cattle fever ticks.
1b.Approach (from AD-416):
In cooperation with the Texas Department of Agriculture and the Texas Animal Health Commission, funds from a sub-grant to the ARS will be used to accelerate a discovery research project for production and laboratory efficacy testing of Bm86-Texas anti-tick vaccine formulation as a tool for integrated approaches to keep the U.S. free of cattle fever ticks.
The objective of this agreement is to produce and evaluate a cattle tick vaccine based on the Bm86-Texas antigen. Sufficient antigen to conduct a 200-head cattle field study has been produced, and a trial in white-tailed deer to evaluate the immunogenicity of the antigen and identify reactive epitopes on the Bm86-Texas protein has been completed.