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United States Department of Agriculture

Agricultural Research Service

Research Project: Mitigating the Risk of Transmission and Environmental Contamination of Transmissible Spongiform Encephalopathies

Location: Animal Diseases Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Primary transmission of CWD versus scrapie prions from small ruminants to ovine and cervid PrP transgenic mice - (Peer Reviewed Journal)
Madsen-Bouterse, S.A., Schneider, D.A., Zhuang, D., Dassanayake, R.P., Balachandran, A., Mitchell, G.B., O'Rourke, K.I. 2016. Primary transmission of CWD versus scrapie prions from small ruminants to ovine and cervid PrP transgenic mice. Journal of General Virology. doi: 10.1099/jgv.0.000539.
Anti-prion activity of DB772 and related monothiophene/furan-based analogs in a persistently infected ovine microglia culture system - (Peer Reviewed Journal)
Dinkel, K.D., Stanton, J.B., Boykin, D.W., Stephens, C.E., Madsen-Bouterse, S.A., Schneider, D.A. 2016. Anti-prion activity of DB772 and related monothiophene/furan-based analogs in a persistently infected ovine microglia culture system. Antimicrobial Agents and Chemotherapy. doi: 10.1128/AAC.00811-16.
A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation - (Peer Reviewed Journal)
Dassanayake, R.P., Zhuang, D., Truscott, T.C., Madsen-Bouterse, S.A., O'Rourke, K.I., Schneider, D.A. 2016. A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation. Prion. 10(2):153-64.
Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep - (Peer Reviewed Journal)
Dassanayke, R.P., Madsen-Bouterse, S.A., Truscott, T.C., Zhuang, D., Mousel, M.R., Davis, W.C., Schneider, D.A. 2016. Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep. BioMed Central (BMC) Veterinary Research. doi: 10.1186/s12917-016-0651-6.
Transcriptomic determinants of scrapie prion propagation in cultured ovine microglia - (Peer Reviewed Journal)
Muñoz-Gutiérrez, J.F., Pierlé, S.A., Schneider, D.A., Baszler, T.V., Stanton, J.B. 2016. Transcriptomic determinants of scrapie prion propagation in cultured ovine microglia. PLoS One. 11(1):e0147727.
Sensitive and specific detection of classical scrapie prions in the brain of goats by real-time quaking-induced conversion - (Peer Reviewed Journal)
Dassanayake, R.P., Orru, C.D., Hughson, A.G., Caughey, B., Graça, T., Zhuang, D., Madsen-Bouterse, S.A., Knowles Jr, D.P., Schneider, D.A. 2016. Sensitive and specific detection of classical scrapie prions in the brain of goats by real-time quaking-induced conversion. Journal of General Virology. (97):803-812.
Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed-dependent - (Peer Reviewed Journal)
Mousel, M.R., White, S.N., Herndon, D.R., Reynolds, J.O., Gonzalez, M., Johnson, W.C., Ueti, M.W., Taylor, J.B., Knowles Jr, D.P. 2015. Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed-dependent. Animal Genetics. 47(1):136-37.
The placenta shed from goats with classical scrapie is infectious to goat kids and lambs - (Peer Reviewed Journal)
Schneider, D.A., Madsen-Bouterse, S.A., Zhuang, D., Truscott, T.C., Dassanayake, R.P., O'Rourke, K.I. 2015. The placenta shed from goats with classical scrapie is infectious to goat kids and lambs. Journal of General Virology. doi: 10.1099/vir.0.000151.
PRNP variants in goats reduce sensitivity of detection of PrPSc by immunoassay - (Peer Reviewed Journal)
Madsen-Bouterse, S.A., Schneider, D.A., Dassanayake, R.P., Truscott, T.C., Zhuang, D., Kumpula-Mcwhirter, N., O'Rourke, K.I. 2015. PRNP variants in goats reduce sensitivity of detection of PrPSc by immunoassay. Journal of Veterinary Diagnostic Investigation. 27(3):332-343.
Role of PRNP S127 allele in experimental goat infection with classical caprine scrapie - (Peer Reviewed Journal)
Dassanayake, R.P., White, S.N., Madsen-Bouterse, S.A., Schneider, D.A., O'Rourke, K.I. 2015. Role of PRNP S127 allele in experimental goat infection with classical caprine scrapie. Animal Genetics. doi: 10.1111/age.12291.
Classical natural ovine scrapie prions are detected in practical volumes of blood by lamb and transgenic mouse bioassay - (Peer Reviewed Journal)
Dassanayake, R.P., Truscott, T.C., Zhuang, D., Schneider, D.A., Madsen-Bouterse, S.A., Young, A.J., Stanton, J.B., Davis, W.C., O’Rourke, K.I. 2015. Classical natural ovine scrapie prions are detected in practical volumes of blood by lamb and transgenic mouse bioassay. Journal of Veterinary Science. 16(2):179-186.
hTERT-immortalized ovine microglia propagate natural scrapie isolates - (Peer Reviewed Journal)
Munoz-Gutierrez, J.F., Schneider, D.A., Baszler, T.V., Dinkel, K.D., Greenlee, J.J., Nicholson, E.M., Stanton, J.J. 2015. hTERT-immortalized ovine microglia propagate natural scrapie isolates. Virus Research. 198:35-43.
Accumulation of PrP-Sc in hemal nodes of naturally and experimentally scrapie-infected sheep     Reprint Icon - (Peer Reviewed Journal)
Dassanayake, R.P., Truscott, T.C., Özyigit, Ö.M., Zhuang, D., Schneider, D.A., O'Rourke, K.I. 2013. Accumulation of PrP-Sc in hemal nodes of naturally and experimentally scrapie-infected sheep. BioMed Central (BMC) Veterinary Research. doi:10.1186/1746-6148-9-82.
Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay - (Peer Reviewed Journal)
Nichols, T.A., Spraker, T.R., Rigg, T.D., Meyerett-Reid, C., Hoover, C., Michel, B., Bian, J., Hoover, E., Gidlewski, T., Balachandran, A., O'Rourke, K., Telling, G.C., Bowen, R., Zabel, M.D., Vercauteren, K.C. 2013. Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay . PLoS Pathogens. DOI:10.1371/journal.pone.0062455.
Linkage between anaplasma marginale outer membrane proteins enhances immunogenicity, but is not required for protection from challenge     Reprint Icon - (Peer Reviewed Journal)
Noh, S.M., Turse, J., Brown, W.C., Norimine, J., Palmer, G.H. 2013. Cross-linking of anaplasma marginale outer membrane proteins enhances immunogenicity, but is not required for protection from challenge. Vaccine. 20(5):651-656.
Immunization with synthetic peptide vaccine fails to protect mule deer (Odocoileus hemionus) from chronic wasting disease - (Peer Reviewed Journal)
Pilon, J.L., Rhyan, J.C., Wolfe, L.L., Davis, T., Mccollum, M.P., O'Rourke, K., Spraker, T.R., Vercauteren, K.C., Miller, M.W., Gidlewski, T., Nichols, T.A., Miller, L.A., Nol, P. 2013. Immunization with synthetic peptide vaccine fails to protect mule deer (Odocoileus hemionus) from chronic wasting disease. Journal of Wildlife Diseases. 49(3):694-698.
Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and rov cells PLoS one - (Peer Reviewed Journal)
Stanton, J.B., Schneider, D.A., Dinkel, K.D., Balmer, B.F., Baszler, T.V., Mathison, B.A., Boykin, D.W. 2012. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and rov cells PLoS one. Antimicrobial Agents and Chemotherapy. PloSone 7(11):e51173.
Efficacy of antemortem rectal biopsies to diagnose and estimate prevalence of chronic wasting disease in free-ranging elk (Cervus elaphus nelsoni)     Reprint Icon - (Peer Reviewed Journal)
Monello, R., Powers, J.G., Hobbs, N.T., Spraker, T.R., O'Rourke, K., Wild, M.A. 2013. Efficacy of antemortem rectal biopsies to diagnose and estimate prevalence of chronic wasting disease in free-ranging elk (Cervus elaphus nelsoni). Journal of Wildlife Diseases. DOI: 10.7589/WD.2011-12-362.
Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay     Reprint Icon - (Peer Reviewed Journal)
Madsen-Bouterse, S.A., Zhuang, D., Orourke, K.I., Schneider, D.A. 2012. Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay. Biochemical and Biophysical Research Communications. 423(4):770-774.
Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America:Effects of age,sex,polymorphism at PRNP codon 96,and disease progression - (Peer Reviewed Journal)
Thomsen, B.V., Schneider, D.A., O'Rourke, K., Gidlewski, T., Mclane, J., Allen, R.W., Mcisaac, A.A., Mitchell, G.B., Keane, D.P., Spraker, T., Balachandran, A. 2012. Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America:Effects of age,sex,polymorphism at PRNP codon 96,and disease progression. J Vet Diagn Invest. 24(5):878-87.
Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus)     Reprint Icon - (Peer Reviewed Journal)
Mitchell, G.B., Sigurdson, C.J., Orourke, K.I., Algire, J., Harrington, N.P., Walther, I., Spraker, T.R., Balachandran, A. 2012. Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS Pathogens. 7(6)e39055.
Last Modified: 8/25/2016
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