1a.Objectives (from AD-416):
The objective of this agreement is to work together to conduct studies examining the effects of phytochemicals on cancer cells and cancer stem cells. Studies will focus on genes important in the process of carcinogenesis.
1b.Approach (from AD-416):
ARS will use cell culture models of prostate cancer cells or prostate cancer stem cells to test the effects of diet-derived phytochemicals on their ability to inhibit carcinogenesis. The focus will be on cellular pathways that may be important in the carcinogenesis process, including steroid hormone-related pathways, xenobiotic metaboism, etc.
Hypercholesterolemia is associated with increase risk of prostate cancer. DGIL and University of Maryland scientists partnered to examine the effects of soy-derived phytochemicals called glyceollins on hypercholesterolemia in hamster model. Glyceollin supplementation significantly reduced plasma VLDL, hepatic cholesterol esters, and total lipid content in hamster. These effects were associated with the changes of cholesterol metabolism related genes. The results support a potential beneficial effect of soy/soy-derived phytochmicals on prostate cancer prevention through lowering cholesterol.