Location: Animal Parasitic Diseases
Project Number: 1245-32000-098-10
Start Date: Jun 01, 2011
End Date: May 31, 2014
ARS has led the PRRS Host Genetics Consortium (PHGC) Project the goal of which is to identify genetic determinants of resistance/susceptibility of commercial swine to PRRSV infection. Many of these studies have been performed with pigs from Canadian sources. The information generated in this Genome Canada proposal will extend the deep phenotyping of existing PHGC samples, will add samples from nursery infection trials with a 2nd PRRSV isolate, and will add a gilt PRRS model. These data will be used by both parties and members of the PHGC to determine genetic alleles and gene and protein expression differences that are associated with PRRS and PCV2 resistance/susceptibility. The Cooperator will perform new PRRSV and PCV2 infection trials, genotype new sets of genomic DNAs and perform RNA-seq and FMIA analyses to identify genes and proteins that differentiate PRRS resistant from susceptible pigs. The Cooperator will apply for funding through the Alberta Livestock Genomics Program grant program.