2012 Annual Report
1)Mosquito screening bioassays: we have screened more than 600 extracts/pure compounds in mosquito larval bioassays. Further screening of the active products was completed at lower dosages. Dose response bioassays were completed for more than 50 compounds/extracts against 1-day old mosquito larvae..
2)More than 500 extracts/natural products were evaluated to determine the biting deterrence effects of these compounds using Klun & Debboun (K & D) modules. Out of these products, replicated bioassays were completed for more than 50 extracts/compounds for publications. We are conducting further elaborated bioassays on products that have shown a promising response in the K&D modules. An additional four manuscripts have been submitted and more manuscripts are being prepared for peer-reviewed journals. These new manuscripts will cover topics such as the biting deterrence and insecticidal activity of hydrazide-hydrazones, the antifungal, mosquito deterrent and larvicidal activity of N-(benzylidene)-3-cyclohexylpropionic acid hydrazide derivatives and 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles against Aedes aegypti, and the biting deterrence and larvicidal activity of Ruta chalepensis L. Essential Oil and its major individual constituents against Aedes aegypti..
3)Lastly, a bioassay system to assess the repellency of natural compounds against fire ants has been developed and has been utilized to evaluate various natural product extracts for efficacy.