Location: Foreign Animal Disease Research
Project Number: 8064-32000-057-37
Start Date: Jan 10, 2012
End Date: Jan 09, 2017
The identified host proteins will be identified by the two hybrid yeast system. Those identified will be further characterized, particularly the molecular interaction between the host and virus proteins. Residues in the host proteins mediating the interaction with the virus proteins will be identified and characterized. Based on that information, the role of those residues in the process of virus replication will be assessed. Monoclonal antibodies specific for the different virus proteins are critical tools for this type of study since they allow the identification of the virus proteins in different methodological procedures to study the characteristics of the interaction between the host and virus proteins.